Search on: GTP PYROPHOSPHOKINASE 
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Descriptor English:   GTP Pyrophosphokinase 
Descriptor Spanish:   GTP Pirofosfoquinasa 
Descriptor Portuguese:   GTP Pirofosfoquinase 
Synonyms English:   ATP Guanosine Phosphate Pyrophosphotransferase
Factor, Stringent
Pyrophosphokinase, GTP
Pyrophosphotransferase, ATP-Guanosine Phosphate
Stringent Factor
ATP-Guanosine Phosphate Pyrophosphotransferase  
Tree Number:   D08.811.913.696.175.300
Definition English:   An enzyme that catalyzes reversibly the transfer of a pyrophosphate group from ATP to the 3'-OH group of GDP or GTP with the formation of guanosine 3'-diphosphate 5'-diphosphate or guanosine 3'-diphosphate 5'-triphosphate and AMP. The enzyme, also called stringent factor, is located in the relA gene in stringent strains of bacteria. The above synthesis is induced by mRNA and uncharged tRNA which is bound to the aminoacyl-t-RNA binding site of the ribosome by a codon-specific association. EC 2.7.6.5. 
History Note English:   92; was ATP-GUANOSINE PHOSPHATE PYROPHOSPHOTRANSFERASE 1980-91 (see under PHOSPHOTRANSFERASES, ATP 1980-90) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   30302 
Unique Identifier:   D001277 

Occurrence in VHL:
 

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